Avivagen’s discovery that oxidized β-carotene (OxBC), containing mostly novel β-carotene-oxygen copolymers in a mixture of flavour-enhancing breakdown compounds, is capable of the supporting immune function and enhancing livestock feed intake has opened up major product opportunities. The copolymer compounds play a major role in contributing support to immune function (see Science section). Several of the breakdown compounds are Generally Recognized As Safe (GRAS) flavouring agents approved for human use. The complex mixture of small amounts of the many co-generated, low molecular weight, breakdown compounds (norisoprenoids) and the copolymer compounds reflects the oxidation process as it occurs naturally in plant materials exposed to air.

OxBC, the richest and purest source of β-carotene-oxygen copolymer compounds, is economically produced synthetically by air-oxidation by a global β-carotene manufacturer.

Commercial OxBC formulations include OxC-beta™ Livestock premix for livestock feeds, and Dr Tobias All-in-One Dog Chews and Vivamune™ Health Chews supplements for companion animals.

The absence of both β-carotene and vitamin A in OxBC points directly to the involvement of β-carotene oxidation products and the β-carotene copolymers in particular as the agents responsible for supporting immune function in a manner that previously was thought to arise instead from vitamin A or intact β-carotene. In the absence of vitamin A, these effects have sometimes been referred to as non-vitamin A effects..

In livestock, the health benefits of OxBC have been shown clearly in various trials with poultry, swine and dairy cattle, using low parts-per-million levels of the compound in feed. Helping support feed intake and immune function supports better health, which can translate into better productivity.

In companion animals such as canines, multiple benefits are observed in a variety of ways that depend on the individual health status of the animals.

Avivagen’s scientific publications report studies that underscore support of immune function being the underlying basis of the variety of benefits observed in animals,

The first-in-class OxBC-based line of products now provide livestock producers and pet owners alike access to the actual source of β-carotene’s non-vitamin A, immune function support, providing consistent and reliable results in maintaining the health of their animals.

OxC-beta™ Livestock, for example, not only is a compelling alternative to antibiotics used for enhancing food production in livestock feeds but also can be beneficial in conditions where antibiotic use is restricted, e.g., in milk-producing dairy cows.

OxC-beta™ Livestock

products-cowFeeding trials in multiple animal species have demonstrated the clear and reproducible benefits of providing OxC-beta™ Livestock, over and above supplemental vitamin A. There being no vitamin A or β-carotene present in OxC- beta™ Livestock, and in the absence of any inherent vitamin A activity, the benefits obtained with OxC-beta supplementation indicate they originate from the β-carotene copolymer compounds in OxC-beta™ Livestock and not from vitamin A or intact β-carotene. Avivagen also has shown that the β-carotene copolymer and related carotenoid copolymer compounds can occur naturally in significant amounts in forages used as livestock feeds, such as alfalfa and grass hays, which, however, apart from special situations, are not normally included in regular modern feed rations.

OxC-beta™ Livestock’s demonstrated beneficial effects in trials with thousands of animals in different countries and under a variety of conditions are consistent with this naturally-occurring, active, transformed form of β-carotene contributing to a better-balanced feed ration by compensating for the lack or deficiency of what is a previously unrecognized forage component.

The general immune-supporting and associated health benefits provided by low levels of OxC-beta™ Livestock have wide applicability. A major global  opportunity is as a compelling and cost-effective alternative to the use of in-feed antibiotics.

Historically, with limited alternatives, the use of antibiotics to promote growth and prevent certain infections in livestock has been viewed as essential to the economics of raising poultry, swine and cattle. Europe, however, prohibited the routine use of antibiotic growth promoters (AGPs) in 2006. Advocacy for the same restrictions to be implemented globally is well established in other countries including the United States, Canada and much of Asia.

The growing pressure on animal food producers to maintain high production and low costs has become a global crisis with the pressing need to stop using in-feed antibiotics to help optimize health and growth. Accordingly, producers have been turning to a variety of non-antibiotic alternatives.

The OxC-beta™ Livestock product has been shown in trials to help animals grow healthier and faster, with comparable feed rations, reducing the single-largest cost in rearing food animals.

OxC-beta™ Livestock is being sold in the Philippines, Thailand and Malaysia.

“This project will further strengthen UNAHCO’s green platform strategy ‘Safe Feed = Safe Food’. We’re very excited to work with Avivagen on their OxC-beta™ Technology, a nature-based feed ingredient that has been shown to enhance immunity and productivity.”

Glen Ibañez, AVP-Technical Services of UNAHCO

Avivagen is currently working with several additional partners to commercialize this exciting opportunity for the benefit of producers and consumers alike.

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Companion Animal Supplements

Avivagen markets two companion animal supplements. Firstly, the Dr Tobias All-in-One Dog Chews that are marketed online, primarily through Amazon.com in the US as well as Dr Tobias.com. Secondly, Avivagen has VivamuneTM Health Chews, which are our retail companion animal brand. Vivamune™ Health ChewsBoth supplements are a tasty, once-a-day supplement to give your dogs the quality of life and optimal health they deserve.

When our pets are healthy on the inside it shows on the outside. From healthy skin to a glossy coat and a spring in his step, your dog will let you know when he’s feeling his best. OxC-beta supplementation Vivamune can help to keep your pet in peak condition and support overall quality of life.

Vivamune™ OxC-beta supplements Chews are suitable for dogs in all life stages and can be given to animals as young as 6 weeks of age. While dogs of any age can benefit from supplementation Vivamune™ Chews, they are especially suitable for older or aging pets benefit most as OxC-beta supplementation to helps support and maintain overall health and promote quality of life. Vivamune™ Chews help to keep dogs in peak condition and helps reduce the negative effects of stress.

Vivamune™ Chews are available as a healthy, tasty soft chew in resealable foil packs containing 60 chews.

Dr Tobias All-in-One Dog Chews are a tasty soft chew in a bottle containing 60 chews.

Every pet is different with regard to health status but most owners should notice a benefit in their pet within 2-4 weeks of giving the chews.

“My English Mastiff has seasonal allergies. We had tried everything and finally found your supplement. I tried your product and I am so happy! Rogue looks great and seems happier. I love it. She loves it!”

Terry-Lyn, Mom to Rogue, gorgeous English Mastiff

Avivagen welcomes enquiries from parties interested in becoming international marketing and distribution partners for its
products. Please direct such enquiries to the attention of the CEO in the Contact Us section of our website or telephone
our head office at 613-949-8164.